Inhibition of Soluble Stem Cell Factor Promotes Intestinal Mucosal Repair.

Vicky Garcia-HernandezArturo Raya-SandinoVeronica AzcutiaJael MirandaMatthias KelmSven FlemmingDorothee BirklMiguel QuirosJennifer C BrazilCharles A ParkosAsma Nusrat

Published in: Inflammatory bowel diseases (2023)

These data demonstrate that SCF functions as a pro-inflammatory mediator in mucosal tissues and that specific neutralization of SCF248 could be a viable therapeutic option to reduce intestinal inflammation and promote mucosal wound repair in individuals with IBD.

Keyphrases

ulcerative colitis
stem cells
oxidative stress
gene expression
electronic health record
bone marrow
wound healing
cell therapy
surgical site infection