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A narrative review on the mechanism of natural flavonoids in improving glucolipid metabolism disorders.

Wenjing NiuYongshi FengMinwen PengJinyan Cai
Published in: Phytotherapy research : PTR (2024)
Glucolipid metabolism disorder (GLMD) is a complex chronic disease characterized by glucose and lipid metabolism disorders with a complex and diverse etiology and rapidly increasing incidence. Many studies have identified the role of flavonoids in ameliorating GLMD, with mechanisms related to peroxisome proliferator-activated receptors, nuclear factor kappa-B, AMP-activated protein kinase, nuclear factor (erythroid-derived 2)-like 2, glucose transporter type 4, and phosphatidylinositol-3-kinase/protein kinase B pathway. However, a comprehensive summary of the flavonoid effects on GLMD is lacking. This study reviewed the roles and mechanisms of natural flavonoids with different structures in the treatment of GLMD reported globally in the past 5 years and provides a reference for developing flavonoids as drugs for treating GLMD.
Keyphrases
  • nuclear factor
  • protein kinase
  • toll like receptor
  • blood glucose
  • risk factors
  • high resolution
  • inflammatory response
  • immune response
  • type diabetes
  • blood pressure