The Prevalence and Association of Exercise Test Abnormalities with Sudden Cardiac Death and Transplant-Free Survival in Childhood Hypertrophic Cardiomyopathy.
Jennifer ConwaySandar MinChet R VillaRobert G WeintraubStephanie NakanoJustin A GodownMark R TatangeloKathryn ArmstrongMarc E RichmondBeth KaufmanAshwin K LalSeshadri BalajiAlyssa PowerNathanya Baez HernandezLetizia GardinPaul F KantorJohn Jerry ParentPeter F AzizJohn Lynn JefferiesAndreea DragulescuAamir JeewaLee N BensonMark W RussellRobert D WhitehillJoseph W RossanoTaylor HowardSeema MitalPublished in: Circulation (2022)
Exercise abnormalities are common in childhood HCM. An abnormal exercise test was independently associated with lower transplant-free survival especially in those with an ischemic or abnormal blood pressure response with exercise. Exercise-induced ischemia was also independently associated with SCD events. These findings argue for routine exercise testing in childhood HCM as part of ongoing risk assessment.
Keyphrases
- free survival
- hypertrophic cardiomyopathy
- high intensity
- physical activity
- blood pressure
- risk assessment
- resistance training
- risk factors
- early life
- heart failure
- type diabetes
- heavy metals
- metabolic syndrome
- heart rate
- oxidative stress
- brain injury
- blood brain barrier
- clinical practice
- ischemia reperfusion injury
- atrial fibrillation
- blood glucose