Associations between fatigue impact and physical and neurobehavioural factors: An exploration in people with progressive multiple sclerosis.
L ConnollyS ChatfieldJ FreemanA SalterM P AmatoG BrichettoJ ChatawayN D ChiaravallotiG CutterJ DeLucaU DalgasR FarrellP FeysM FilippiM IngleseC MezaN B MooreR W MotlM A RoccaB M SandroffA FeinsteinPublished in: Multiple sclerosis and related disorders (2024)
and neurobehavioural measures of anxiety (r = 0.56), depression (r = 0.59), and measures of disease impact (MSIS-physical r = 0.67; MSIS-mental r = 0.71). This pattern was broadly similar for the MSIF subscales. The multivariable model indicated a five-point increase in MSWS-12 was associated with a 14 % increase in the odds of being fatigued (OR [95 %CI]: 1.14 [1.07-1.22], p < 0.0001) CONCLUSION: Management of fatigue should consider both physical and neurobehavioural factors, in cognitively impaired persons with progressive MS.