Contrasting role of NLRP12 in autoinflammation: evidence from a case report and mouse models.

Dan LévyAlexandre MariotteAurore DeCauwerCecile MacquinAngélique PichotAnne MolitorFrancois MaurierAlain MeyerRaphael CarapitoPhilippe Georgel

Published in: RMD open (2022)

Nlrp12 mediates proinflammatory functions in mice. In humans, the identification of Nlrp12 variants must be cautiously interpreted depending on clinical and paraclinical data to diagnose FCAS-2.

Keyphrases

nlrp inflammasome
mouse model
copy number
electronic health record
high fat diet induced
big data
bioinformatics analysis
dna methylation
insulin resistance
deep learning
skeletal muscle
adipose tissue
genome wide