The polymorphic variant of SerpinB3 (SerpinB3-PD) is associated with faster cirrhosis decompensation.
Andrea MartiniCristian TuratoStefania CannitoSantina QuartaAlessandra BiasioloMariagrazia RuvolettoErica NovoFilippo MarafattoPietro GuerraMarta TononNausicaa ClementeClaudia BoccaSalvatore Silvio PianoMaria GuidoDario GregoriMaurizio ParolaPaolo AngeliPatrizia PontissoPublished in: Alimentary pharmacology & therapeutics (2023)
The polymorphic variant SB3-PD is highly effective in determining activation of TGF-β1 and inflammation in vitro. Patients with cirrhosis who carry SB3-PD polymorphism may be more prone to develop severe liver disease progression. However, further validation studies are warranted to support the in vivo relevance of this polymorphism.