Monocyte NLRP3 inflammasome and interleukin-1β activation modulated by alpha-1 antitrypsin therapy in deficient individuals.
Debananda GogoiHoward YuMichelle CaseyRory BairdAzeez YusufLuke FordeMichael E O' BrienJesse R WestTammy FlaggNoel G McElvaneyEdward EdenChristian MuellerMark L BrantlyPatrick GeraghtyEmer P ReevesPublished in: Thorax (2024)
These results provide strong insight into the mechanism of complement-driven inflammation associated with AATD. Although the described variance in C3d and NLRP3 activation decreased post AAT augmentation therapy, results demonstrate persistent C3d and monocyte ER stress, with implications for new therapeutics and clinical practice.