Role of Sam68 as an adaptor protein in inflammatory signaling.
Vemana GowdJoseph D'Amato KassNandini SarkarParameswaran RamakrishnanPublished in: Cellular and molecular life sciences : CMLS (2024)
Sam68 is a ubiquitously expressed KH-domain containing RNA-binding protein highly studied for its involvement in regulating multiple steps of RNA metabolism. Sam68 also contains multiple protein-protein interaction regions such as proline-rich regions, tyrosine phosphorylation sites, and arginine methylation sites, all of which facilitate its participation as an adaptor protein in multiple signaling pathways, likely independent of its RNA-binding role. This review focuses on providing a comprehensive report on the adaptor roles of Sam68 in inflammatory signaling and inflammatory diseases. The insights presented here have the potential to open new avenues in inflammation research and justify targeting Sam68 to control aberrant inflammatory responses.
Keyphrases
- protein protein
- binding protein
- oxidative stress
- small molecule
- signaling pathway
- nitric oxide
- amino acid
- nucleic acid
- minimally invasive
- physical activity
- dna methylation
- gene expression
- epithelial mesenchymal transition
- genome wide
- climate change
- risk assessment
- drug delivery
- cell proliferation
- induced apoptosis
- human health
- protein kinase