Bioactive NIR-II Light-Responsive Shape Memory Composite Based on Cuprorivaite Nanosheets for Endometrial Regeneration.
Chenle DongChen YangMuhammad Rizwan YounisJing ZhangGang HeXingdi QiuLian-Hua FuDong-Yang ZhangHao WangWenli HongJing LinXueqing WuPeng HuangPublished in: Advanced science (Weinheim, Baden-Wurttemberg, Germany) (2022)
Intrauterine adhesions (IUAs) caused by mechanical damage or infection increase the risk of infertility in women. Although numerous physical barriers such as balloon or hydrogel are developed for the prevention of IUAs, the therapeutic efficacy is barely satisfactory due to limited endometrial healing, which may lead to recurrence. Herein, a second near-infrared (NIR-II) light-responsive shape memory composite based on the combination of cuprorivaite (CaCuSi 4 O 10 ) nanosheets (CUP NSs) as photothermal conversion agents and polymer poly(d,l-lactide-co-trimethylene carbonate) (PT) as shape memory building blocks is developed. The as-prepared CUP/PT composite possesses excellent shape memory performance under NIR-II light, and the improved operational feasibility as an antiadhesion barrier for the treatment of IUAs. Moreover, the released ions (Cu, Si) can stimulate the endometrial regeneration due to the angiogenic bioactivity. This study provides a new strategy to prevent IUA and restore the injured endometrium relied on shape memory composite with enhanced tissues reconstruction ability.
Keyphrases
- working memory
- photodynamic therapy
- stem cells
- drug release
- cancer therapy
- drug delivery
- quantum dots
- fluorescence imaging
- polycystic ovary syndrome
- fluorescent probe
- mental health
- highly efficient
- type diabetes
- oxidative stress
- metabolic syndrome
- wound healing
- aqueous solution
- room temperature
- pregnancy outcomes
- transition metal
- free survival