Evaluation of eight melanocytic and neural crest-associated markers in a well-characterised series of 124 malignant peripheral nerve sheath tumours (MPNST): useful to distinguish MPNST from melanoma?
Margot GaspardLaurence LamantEmilie TournierThibaud ValentinPhilippe RochaixPhilippe TerrierDominique Ranchere-VinceJean-Michel CoindreThomas FilleronSophie Le GellecPublished in: Histopathology (2018)
MPNST (in NF1 and a sporadic setting) can quite often be positive for Melan-A, tyrosinase and MITF. Pathologists should be cognisant of these exceptions to prevent confusion with melanoma.