A genetic interaction of NRXN2 with GABRE, SYT1 and CASK in migraine patients: a case-control study.

Miguel Alves-FerreiraMarlene QuintasJorge SequeirosAlda SousaJosé Pereira-MonteiroIsabel AlonsoJoão Luís NetoCarolina Lemos

Published in: The journal of headache and pain (2021)

This study unravels, for the first time, the gene-gene interactions between NRXN2, GABRE - a GABAA-receptor - and CASK, importantly it shows the synergetic effect between those genes and its relation with migraine susceptibility. These gene interactions, which may be a part of a larger network, can potentially help us in better understanding migraine aetiology and in development of new therapeutic approaches.

Keyphrases

genome wide
copy number
genome wide identification
end stage renal disease
dna methylation
ejection fraction
newly diagnosed
prognostic factors
genome wide analysis
gene expression