Comparative Structural Analysis of Human ACE2 Receptor with Spike Protein of SARS-CoV-2 Variants: Implications to Understand Infectivity of the Virus.

Tirthankar KoleyArunima GoswamiManoj KumarNeelam UpadhyayGururao Hariprasad

Published in: Advances and applications in bioinformatics and chemistry : AABC (2022)

Different mutations on RBD of spike protein results in varying quantity and quality of interactions, thereby affecting potency of each variant. Variations in binding are due to interactions of mutant residues and induced conformational changes on loops of RBDs. Variants α and β have a low potency, while, γ, δ, and omicron have a higher potency. These results correlate with viral infectivity and place clinical observations in the right perspective.

Keyphrases

sars cov
binding protein
endothelial cells
copy number
high glucose
protein protein
amino acid
respiratory syndrome coronavirus
molecular dynamics
molecular dynamics simulations
single molecule
angiotensin ii
gene expression
induced pluripotent stem cells
drug induced
dna methylation
coronavirus disease