Two-point-NGS analysis of cancer genes in cell-free DNA of metastatic cancer patients.

Maria PalmieriMargherita BaldassarriFrancesca FavaAlessandra FabbianiElisa GelliRossella TitaPamela TorreRoberto PetrioliTheodora HadijstilianouDaniela GalimbertiElisa CinottiCarmelo BengalaMarco MandalàPietro PiuSalvatora Tindara MianoIgnazio MartellucciAgnese VanniniAnna Maria PintoMaria Antonietta MencarelliStefania MarsiliAlessandra RenieriElisa Frullanti

Published in: Cancer medicine (2020)

Irrespective of the primary tumor mutational burden, few mutated genes are present at disease progression. Clinical outcome is consistent with variation of allele frequency of specific clones indicating that cfDNA two-point-NGS analysis of cancer driver genes could be an efficacy tool for precision oncology.

Keyphrases

papillary thyroid
genome wide
squamous cell
bioinformatics analysis
genome wide identification
squamous cell carcinoma
small cell lung cancer
lymph node metastasis
dna methylation
childhood cancer
risk factors
transcription factor
young adults