Earlier relapse detection after allogeneic haematopoietic stem cell transplantation by chimerism assays: Digital PCR versus quantitative real-time PCR of insertion/deletion polymorphisms.

Jennifer Valero-GarciaMaría Del Carmen González-EspinosaManuel BarriosGreta Carmona-AntoñanzasJavier García-PlanellsCarlos Ruiz-LaforaAinhoa Fuentes-GálvezAntonio Jiménez-Velasco

Published in: PloS one (2019)

In conclusion, chimerism determination by dPCR constitutes a suitable technique for the follow-up of patients with haematological pathologies after allo-STC, showing greater sensitivity to predict an early relapse.

Keyphrases

stem cell transplantation
real time pcr
allogeneic hematopoietic stem cell transplantation
high dose
free survival
high resolution
high throughput
acute myeloid leukemia
solid phase extraction
acute lymphoblastic leukemia
molecularly imprinted
mass spectrometry
sensitive detection