Therapeutic targeting of prenatal pontine ID1 signaling in diffuse midline glioma.

Dana MessingerMicah K HarrisJessica R CummingsChase ThomasTao YangStefan R SwehaRinette WooRobert SiddawayMartin BurkertStefanie StallardTingting QinBrendan MullanRuby SiadaRamya RavindranMichael NiculceaAbigail DowlingJoshua BradinKevin F GinnMelissa A H GenerKathleen DorrisNicholas A VitanzaSusanne V SchmidtJasper SpitzerLi JiangMariella G FilbinXuhong CaoMaria G CastroPedro R LowensteinRajen ModyArul ChinnaiyanPierre-Yves DesprezSean McAllisterMatthew D DunCynthia HawkinsSebastian M WaszakSriram VennetiCarl J KoschmannViveka Nand Yadav

Published in: Neuro-oncology (2022)

H3K27M-mediated re-activation of ID1 in DMG results in a SPARCL1+ migratory transcriptional program that is therapeutically targetable with CBD.

Keyphrases

pregnant women
quality improvement
gene expression
low grade
transcription factor
cancer therapy