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The P2X7 receptor-NLRP3 inflammasome complex predicts the development of non-Hodgkin's lymphoma in Sjogren's syndrome: a prospective, observational, single-centre study.

C BaldiniE SantiniC RossiV DonatiAnna Solini
Published in: Journal of internal medicine (2017)
We propose the P2X7R-inflammasome axis as a novel potential pathway involved in both SS exocrinopathy and lymphomagenesis, reinforcing the hypothesis of a key role of IL-18, via its increased P2X7R-mediated production, in the pathogenesis of lymphoproliferative malignancies, and opening novel opportunities for the early diagnosis of lymphoproliferative complications and the development of potential targeted therapies.
Keyphrases
  • nlrp inflammasome
  • epstein barr virus
  • diffuse large b cell lymphoma
  • human health
  • risk factors
  • case report
  • climate change
  • binding protein