The positive feedback loop of MAD2L1/TYK2/STAT3 induces progression in B-cell acute lymphoblastic leukaemia.

Liwen ZhuXinyu LiDiandian LiuWenke BaiHuaqing YangQianyi ChengLuhong XuJian-Pei Fang

Published in: Journal of cancer research and clinical oncology (2023)

This study uncovered a reciprocal loop of MAD2L1/TYK2/STAT3, which contributed to the development of B-ALL. Therefore, MAD2L1 can be considered a potential diagnostic biomarker as well as a novel therapeutic target for B-ALL.

Keyphrases

cell proliferation
liver failure
transcription factor
respiratory failure
risk assessment
intensive care unit