Proteome-Wide Analysis Using SOMAscan Identifies and Validates Chitinase-3-Like Protein 1 as a Risk and Disease Marker of Delirium Among Older Adults Undergoing Major Elective Surgery.
Sarinnapha M VasunilashornSimon T DillonNoel Y ChanTamara G FongMarie JosephBridget TrippZhongcong XieLong H NgoChun Geun LeeJack A EliasHasan H OtuSharon K InouyeMarcantonio ErTowia A LibermannPublished in: The journals of gerontology. Series A, Biological sciences and medical sciences (2022)
Our identification of CHI3L1/YKL-40 in postoperative delirium parallels reports of CHI3L1/YKL-40 and its association with aging, mortality, and age-related conditions including AD onset and progression. This highlights the type 2 innate immune response, involving CHI3L1/YKL-40, as an underlying mechanism of postoperative delirium, a common, morbid, and costly syndrome that threatens the independence of older adults.
Keyphrases
- immune response
- patients undergoing
- cardiac surgery
- hip fracture
- minimally invasive
- physical activity
- acute kidney injury
- coronary artery bypass
- cardiovascular events
- bariatric surgery
- genome wide
- risk factors
- cardiovascular disease
- case report
- coronary artery disease
- gene expression
- emergency department
- inflammatory response
- surgical site infection