Proteome-Wide Analysis Using SOMAscan Identifies and Validates Chitinase-3-Like Protein 1 as a Risk and Disease Marker of Delirium Among Older Adults Undergoing Major Elective Surgery.
Sarinnapha M VasunilashornSimon T DillonNoel Y ChanTamara G FongMarie JosephBridget TrippZhongcong XieLong H NgoChun Geun LeeJack A EliasHasan H OtuSharon K InouyeMarcantonio ErTowia A LibermannPublished in: The journals of gerontology. Series A, Biological sciences and medical sciences (2022)
Our identification of CHI3L1/YKL-40 in postoperative delirium parallels reports of CHI3L1/YKL-40 and its association with aging, mortality, and age-related conditions including AD onset and progression. This highlights the type 2 innate immune response, involving CHI3L1/YKL-40, as an underlying mechanism of postoperative delirium, a common, morbid, and costly syndrome that threatens the independence of older adults.
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