Amygdala atrophies in specific subnuclei in preclinical Alzheimer's disease.

Yasmine Salman Thomas Gérard Lara Huyghe Lise Colmant Lisa Quenon Vincent MalotauxAdrian IvanoiuRenaud Lhommel Laurence Dricot Bernard J Hanseeuwnull null

Published in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2024)

Amygdala atrophy is not homogeneous in preclinical Alzheimer's disease (AD). Tau pathology is associated with atrophy of specific amygdala subnuclei, specifically, the central, medial, cortical, and accessory basal subnuclei. Hippocampal and amygdala volume is not associated with tau in preclinical AD. Hippocampus and CA1-3 volume is reduced in preclinical AD, regardless of tau.

Keyphrases

functional connectivity
prefrontal cortex
resting state
temporal lobe epilepsy
cell therapy
cerebrospinal fluid
cognitive decline