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Toll-like receptor 4 stimulation with monophosphoryl lipid A ameliorates motor deficits and nigral neurodegeneration triggered by extraneuronal α-synucleinopathy.

Serena VeneziaVioletta RefoloAlexia PolissidisLeonidas StefanisGregor K WenningNadia Stefanova
Published in: Molecular neurodegeneration (2017)
Our findings demonstrate beneficial effects of chronic MPLA treatment in transgenic PLP-α-syn mice. MPLA appears to be an attractive therapeutic candidate for disease modification trials in MSA and related α-synucleinopathies.
Keyphrases
  • toll like receptor
  • nuclear factor
  • inflammatory response
  • immune response
  • traumatic brain injury
  • high fat diet induced
  • mouse model
  • combination therapy