Toll-like receptor 4 stimulation with monophosphoryl lipid A ameliorates motor deficits and nigral neurodegeneration triggered by extraneuronal α-synucleinopathy.

Serena VeneziaVioletta RefoloAlexia PolissidisLeonidas StefanisGregor K WenningNadia Stefanova

Published in: Molecular neurodegeneration (2017)

Our findings demonstrate beneficial effects of chronic MPLA treatment in transgenic PLP-α-syn mice. MPLA appears to be an attractive therapeutic candidate for disease modification trials in MSA and related α-synucleinopathies.

Keyphrases

toll like receptor
nuclear factor
inflammatory response
immune response
traumatic brain injury
high fat diet induced
mouse model
combination therapy