Toll-like receptor 4 stimulation with monophosphoryl lipid A ameliorates motor deficits and nigral neurodegeneration triggered by extraneuronal α-synucleinopathy.
Serena VeneziaVioletta RefoloAlexia PolissidisLeonidas StefanisGregor K WenningNadia StefanovaPublished in: Molecular neurodegeneration (2017)
Our findings demonstrate beneficial effects of chronic MPLA treatment in transgenic PLP-α-syn mice. MPLA appears to be an attractive therapeutic candidate for disease modification trials in MSA and related α-synucleinopathies.