Identification of Ubr1 as an amino acid sensor of steatosis in liver and muscle.

Wanni ZhaoYansong ZhangSiyuan LinYajuan LiAlan Jian ZhuHanping ShiMin Liu

Published in: Journal of cachexia, sarcopenia and muscle (2023)

We identified Ubr1 as an amino acid sensor regulating Plin2 proteostasis, bridging the knowledge gap between steatosis and nutrient sensing. Our work may provide new strategies for the prevention and treatment of steatosis.

Keyphrases

amino acid
insulin resistance
high fat diet
high fat diet induced
skeletal muscle
healthcare
adipose tissue
type diabetes
metabolic syndrome
combination therapy
endoplasmic reticulum