Diphenyl Ether Derivative Rhexocerins and Rhexocercosporins from the Endophytic Fungus Rhexocercosporidium sp. Dzf14 Active against Gram-Positive Bacteria with Multidrug-Resistance.
Gan GuXiao GongDan XuYonglin YangRuya YinJun-Gui DaiKui ZhuDaowan LaiLi-Gang ZhouPublished in: Journal of natural products (2023)
Ten new diphenyl ether polyketides, including rhexocerins A-D ( 1 - 4 ) and rhexocercosporins A-F ( 5 - 10 ), together with three known congeners ( 11 - 13 ), were isolated from the endophytic fungus Rhexocercosporidium sp. Dzf14 obtained from Dioscorea zingiberensis . Their structures were elucidated by analysis of NMR and HRESIMS data, and their absolute configurations were determined by quantum chemical ECD calculations and X-ray crystallography. Compounds 1 - 4 featured an unprecedented tetracyclic carbon skeleton (6/7/5/6). Among them, compounds 1 and 5 - 9 showed antibacterial activities against methicillin-resistant S. aureus T144 and vancomycin-resistant E. faecalis 10.
Keyphrases
- high resolution
- molecular dynamics
- methicillin resistant staphylococcus aureus
- staphylococcus aureus
- magnetic resonance
- density functional theory
- ionic liquid
- gram negative
- monte carlo
- electronic health record
- molecular dynamics simulations
- big data
- mass spectrometry
- silver nanoparticles
- magnetic resonance imaging
- machine learning
- dual energy
- multidrug resistant
- solid state
- data analysis
- wound healing
- quantum dots
- cell wall