Prevalence of Lynch syndrome in women with mismatch repair-deficient ovarian cancer.

Rachel Hodan Kerry KinghamKristina CotterAnn K FolkinsAllison W Kurian James M FordTeri Longacre

Published in: Cancer medicine (2020)

Most ovarian cancers with somatic MMR-D were confirmed to have LS in this cohort. Germline testing for LS in addition to BRCA1/2 for all women with an epithelial ovarian cancer would be efficient and would approach 100% sensitivity for identifying Lynch syndrome. Utilization of a multigene panel should also be considered, given the additional non-Lynch germline mutation identified in this cohort.

Keyphrases

dna repair
case report
risk factors
copy number
gene expression
dna damage
young adults
dna methylation
genome wide
breast cancer risk