The Significance of Matrix Metalloproteinase 9 (MMP-9) and Metalloproteinase 2 (MMP-2) in Urinary Bladder Cancer.

Jacek KudelskiAnna Tokarzewicz Monika Gudowska-Sawczuk Barbara MroczkoPiotr ChłostaMarta Bruczko-GoralewskaPrzemysław Mitura Grzegorz Młynarczyk

Published in: Biomedicines (2023)

In conclusion, the content and specific activity of MMP-9 were increased in comparison with MMP-2. The revealed differences in content and activity of both MMPs demonstrate their different participation in ECM remodeling at different stages of cancer development. Moreover, it seems that MMP-9 has higher clinical utility than MMP-2 as a potential therapeutic option and a diagnostic biomarker of urinary bladder cancer.

Keyphrases

cell migration
papillary thyroid
physical activity
single cell
lymph node metastasis
young adults