Molecular Mechanics Simulations and Experimental Investigation of the Effect of Tadalafil on Various Inflammatory Pain Mediators.

Souraya A DomiatiKhaled Abd El GalilHanan M Ragab

Published in: ACS omega (2022)

Tadalafil probably exerts its analgesic effect through the simultaneous inhibition of iNOS, COX-2, and TNF-α, which is not the case with other nonsteroidal anti-inflammatory drugs. Nevertheless, further studies are required to confirm its mechanism.

Keyphrases

anti inflammatory drugs
neuropathic pain
lower urinary tract symptoms
benign prostatic hyperplasia
chronic pain
rheumatoid arthritis
pain management
oxidative stress
molecular dynamics
spinal cord
nitric oxide synthase
case control
nitric oxide