How to design a dose-finding study using the continual reassessment method.

Graham Mark WheelerAdrian P ManderAlun BeddingKristian BrockVictoria CorneliusAndrew P GrieveThomas JakiSharon B LoveLang'o OdondiChristopher J WeirChristina YapSimon J Bond

Published in: BMC medical research methodology (2019)

The framework and resources we provide are aimed at clinicians and statisticians new to the CRM design. Provision of key resources in this contemporary guidance paper will hopefully improve the uptake of the CRM in phase I dose-finding trials.

Keyphrases

palliative care