A real-world observation of patients with glioblastoma treated with a personalized peptide vaccine.
Pauline LatzerHenning ZelbaFlorian BattkeAnnekathrin ReinhardtBorong ShaoOliver BartschArmin RabsteynJohannes HarterMartin SchulzeThomas OkechAlexander GolfChristina Kyzirakos-FegerSimone KayserNatalia PieperMagdalena FeldhahnJulian WünscheChristian SeitzDirk HadaschikClaus GarbeTill-Karsten HauserChristian Peter la FougèreDirk BiskupDawn BrookeDavid ParkerUwe M MartensGerald IllerhausDeborah T BlumenthalRyan MerrellLuisa Sánchez LorenzoMáté HidvégiPaula de RoblesSied KebirWilliam W LiVincent W LiMatthew WilliamsAlexandra M MillerSantosh KesariMichael CastroAnnick DesjardinsDavid M AshleyHenry S FriedmanPatrick Y WenElisabeth C NeilFabio M IwamotoBence SiposKarsten GeletnekyLars ZenderMartin GlasDavid A ReardonSaskia BiskupPublished in: Nature communications (2024)
Current treatment outcome of patients with glioblastoma (GBM) remains poor. Following standard therapy, recurrence is universal with limited survival. Tumors from 173 GBM patients are analysed for somatic mutations to generate a personalized peptide vaccine targeting tumor-specific neoantigens. All patients were treated within the scope of an individual healing attempt. Among all vaccinated patients, including 70 treated prior to progression (primary) and 103 treated after progression (recurrent), the median overall survival from first diagnosis is 31.9 months (95% CI: 25.0-36.5). Adverse events are infrequent and are predominantly grade 1 or 2. A vaccine-induced immune response to at least one of the vaccinated peptides is detected in blood samples of 87 of 97 (90%) monitored patients. Vaccine-specific T-cell responses are durable in most patients. Significantly prolonged survival is observed for patients with multiple vaccine-induced T-cell responses (53 months) compared to those with no/low induced responses (27 months; P = 0.03). Altogether, our results highlight that the application of personalized neoantigen-targeting peptide vaccine is feasible and represents a promising potential treatment option for GBM patients.