Toxicological effects of bioactive peptide fractions obtained from Bothrops jararaca snake venom on the structure and function of mouse seminiferous epithelium.
Carlos Alberto-SilvaCelline Sampaio FranzinJoyce Meire GilioRodrigo Simão BonfimSamyr Machado QuerobinoPublished in: The journal of venomous animals and toxins including tropical diseases (2020)
The major finding of the present study was that the LMWF inhibited spermatozoa production; principally in the spermiogenesis stage without altering claudin-1 distribution in the basal compartment. Moreover, NO increased by LMWF induce open of complexes junctions and release the germ cells of the adluminal compartment to the seminiferous tubule.