Pharmacological Modulation by Low Molecular Weight Heparin of Purinergic Signaling in Cardiac Cells Prevents Arrhythmia and Lethality Induced by Myocardial Infarction.
Carlos Eduardo Braga FilhoAdriano Henrique Pereira BarbosaLucas Antonio Duarte NicolauJand Venes Rolim MedeirosMarcelo Pires-OliveiraRui Manuel Dos Santos PóvoaTânia Carmen Penãranda GovatoHézio Jadir Fernandes JúniorRafael Guzella de CarvalhoBráulio Luna-FilhoFernando Sabia TalloErisvaldo Amarante de AraújoJosé Gustavo Padrão TavaresRicardo Mario AridaAfonso Caricati-NetoFrancisco Sandro Menezes-RodriguesPublished in: Journal of cardiovascular development and disease (2023)
These results indicate that ENOX was effective in preventing severe and lethal arrhythmias induced by CIR due to pharmacological modulation of ADO signaling in cardiac cells, suggesting that this cardioprotective strategy could be promising in AMI therapy.
Keyphrases
- induced apoptosis
- left ventricular
- cell cycle arrest
- heart failure
- acute myocardial infarction
- endoplasmic reticulum stress
- stem cells
- venous thromboembolism
- oxidative stress
- growth factor
- mesenchymal stem cells
- mouse model
- signaling pathway
- early onset
- cell death
- percutaneous coronary intervention
- smoking cessation