Erythropoietin protects outer blood-retinal barrier in experimental diabetic retinopathy by up-regulating ZO-1 and occludin.

Chaoyang ZhangHai XieQian YangYiting YangWeiye LiHaibin TianLixia LuFang WangJing-Ying XuFurong GaoJuan WangCaixia JinGuoxu XuGuo-Tong XuJingfa Zhang

Published in: Clinical & experimental ophthalmology (2019)

In early diabetic rats, the outer BRB might be more severely damaged and its breakdown is the major factor for retinal oedema. EPO maintains the outer BRB integrity through down-regulation of HIF-1α and JNK signallings, and thus up-regulating ZO-1 and occludin expressions in RPE cells.

Keyphrases

diabetic retinopathy
diabetic rats
induced apoptosis
optical coherence tomography
oxidative stress
cell cycle arrest
signaling pathway
endoplasmic reticulum stress
cell death
endothelial cells
pi k akt