A fast responsive and cell membrane-targetable near-infrared H 2 S fluorescent probe for drug resistance bioassays in chemotherapy.
Yifan HeWei HuLi ChaiYanying WangXian WangTao LiangHaiyan LiChunya LiPublished in: Chemical communications (Cambridge, England) (2022)
A cell membrane-targeted near-infrared fluorescent probe, CMCu-H 2 S, was fabricated through employing hydrophobic chains and cyclen-Cu 2+ as targeting and recognition groups, respectively. NIR fluorescence of CMCu-H 2 S can significantly increase after reacting with H 2 S by removing the quenchable Cu 2+ . This probe exhibited high selectivity and an extremely fast response rate. Cell imaging results demonstrated that there was a close relationship between the overexpression of NFS1 and drug resistance and inhibition of NFS1 was beneficial for improving the efficacy of chemotherapy.
Keyphrases
- fluorescent probe
- living cells
- cancer therapy
- aqueous solution
- locally advanced
- high resolution
- single cell
- drug delivery
- single molecule
- cell proliferation
- cell therapy
- transcription factor
- rectal cancer
- quantum dots
- squamous cell carcinoma
- stem cells
- ionic liquid
- radiation therapy
- mass spectrometry
- mesenchymal stem cells