SNAr Radiofluorination with In Situ Generated [18F]Tetramethylammonium Fluoride.

So Jeong LeeMaría T Morales-Colón Allen F Brooks Jay S WrightKatarina J MakaravagePeter J H Scott Melanie S Sanford

Published in: The Journal of organic chemistry (2021)

This report describes a method for the nucleophilic radiofluorination of (hetero)aryl chlorides, (hetero)aryl triflates, and nitroarenes using a combination of [18F]KF·K2.2.2 and Me4NHCO3 for the in situ formation of a strongly nucleophilic fluorinating reagent (proposed to be [18F]Me4NF). This method is applied to 24 substrates bearing diverse functional groups, and it generates [18F](hetero)aryl fluoride products in good to excellent radiochemical yields in the presence of ambient air/moisture. The reaction is applied to the preparation of 18F-labeled HQ-415 for potential (pre)clinical use.

Keyphrases

drinking water
air pollution
signaling pathway
particulate matter
lps induced
oxidative stress
pi k akt
pet imaging
cell proliferation
high resolution