Therapeutic induction of Bcl2-associated athanogene 3-mediated autophagy in idiopathic pulmonary fibrosis.
Shashipavan ChillappagariJulian SchwarzVidyasagar KesireddyJessica KnoellMartina KorfeiKonrad HoetzeneckerM Lienhard SchmitzChristian BehlSaverio BellusciAndreas GuentherPoornima MahavadiPublished in: Clinical and translational medicine (2022)
Our study reveals that repurposing drugs that modulate autophagy regulating proteins render therapeutic benefits in IPF. Fine tuning of this pathway may hence signify a promising therapeutic strategy to ameliorate antifibrotic properties and augment the efficacy of current IPF therapy.