The sputum transcriptome better predicts COPD exacerbations after the withdrawal of inhaled corticosteroids than sputum eosinophils.

Benedikt DitzAartik SarmaHuib A M KerstjensJeroen J W LieskerErik BathoornJudith E VonkVictor BernalPeter HorvatovichVictor GuryevSaharai CalderaChaz LangelierAlen FaizStephanie A ChristensonMaarten van den Berge

Published in: ERJ open research (2021)

We identified a sputum gene expression signature that exhibited a higher predictive value for predicting COPD exacerbations after ICS withdrawal than sputum eosinophilia. Future studies should investigate the utility of this signature, which might enhance personalised ICS treatment in COPD patients.

Keyphrases

cystic fibrosis
lung function
chronic obstructive pulmonary disease
gene expression
pulmonary tuberculosis
mycobacterium tuberculosis
end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
dna methylation
peritoneal dialysis
rna seq
patient reported outcomes