Using Genomic Tools to Predict Antimicrobial Resistance and Markers in Clinical Bacterial Samples.
Tony Hong-Wei ChangJulie D PourtoisNaomi L HaddockDaisuke FurkuawaThomas HongDerek AmanatullahElizabeth BurgenerPaul L BollykyPublished in: bioRxiv : the preprint server for biology (2024)
This study investigates the impact of prophages on antibiotic resistance in two clinically significant bacteria, Pseudomonas aeruginosa and Staphylococcus aureus. Understanding how prophages influence resistance mechanisms in these pathogens is crucial, as Pseudomonas aeruginosa is known for its role in chronic infections in cystic fibrosis patients, while Staphylococcus aureus, including MRSA strains, is a leading cause of hospital-acquired infections. By exploring the relationship between prophage presence and resistance, this research provides insights that could inform the development of more effective treatment strategies and enhance our ability to combat antibiotic-resistant infections, ultimately improving patient outcomes and public health.
Keyphrases
- pseudomonas aeruginosa
- staphylococcus aureus
- cystic fibrosis
- antimicrobial resistance
- biofilm formation
- public health
- methicillin resistant staphylococcus aureus
- ejection fraction
- end stage renal disease
- newly diagnosed
- acinetobacter baumannii
- escherichia coli
- healthcare
- lung function
- emergency department
- prognostic factors
- patient reported outcomes
- peritoneal dialysis
- multidrug resistant
- genome wide