Renal cell carcinoma in children and adolescents: a retrospective study of a French-Italian series of 93 cases.
Thomas DenizeSimona MassaAlexander ValentLucia MilittiAlessia BertolottiMarta BarisellaNathalie Rioux-LeclercqGabriel G MaloufFilippo SpreaficoArnauld VerschuurJustine van der BeekLieve TytgatMarry M van den Heuvel-EibrinkGordan M VujanicPaola ColliniAurore CoulombPublished in: Histopathology (2022)
A precise histological diagnosis is mandatory, as targeted therapy could be applied for some RCC subtypes, i.e. MiTF-translocation and ALK-translocation RCC. Moreover, some RCC subtypes may be associated with a predisposition syndrome that will impact patients' and family's management and genetic counselling. A precise RCC subtype is also mandatory for the clinical management of the patients and inclusion in new prospective clinical trials.