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Treatment of BRAF -V600E mutant metastatic colorectal cancer: new insights and biomarkers.

Javier RosMarta Rodríguez-CastellsNadia SaoudiIosune BaraibarFrancesc SalvaJosep TaberneroElena Élez
Published in: Expert review of anticancer therapy (2023)
There is a crucial need to better understand tumor biology and develop accurate and reliable biomarkers to enhance the antitumor activity of encorafenib-based combinations. The RNF43 mutation is an accurate and reliable predictive biomarker of response, and combinations that target crosstalk between the MAPK pathway, the immune system, and WNT pathways seem promising.
Keyphrases
  • metastatic colorectal cancer
  • high resolution
  • signaling pathway
  • stem cells
  • cell proliferation
  • wild type
  • pi k akt
  • combination therapy
  • mass spectrometry
  • dna damage response
  • replacement therapy
  • smoking cessation