Prognostic value of HLA-I homozygosity in patients with non-small cell lung cancer treated with single agent immunotherapy.

Afaf AbedLeslie CalapreJohnny LoSuzana CorreiaSamantha BowyerAbha ChopraMark WatsonMuhammad Adnan KhattakMichael MillwardElin Solomonovna Gray

Published in: Journal for immunotherapy of cancer (2021)

Our results suggest that homozygosity at ≥1 HLA-I loci is associated with short OS and PFS in patients with advanced non-small cell lung cancer with PDL1 ≥50% treated with single-agent immunotherapy. Carriers of HLA-A02 supertype reported better survival outcomes in this cohort of patients.

Keyphrases

advanced non small cell lung cancer
newly diagnosed
end stage renal disease
ejection fraction
chronic kidney disease
epidermal growth factor receptor
peritoneal dialysis
prognostic factors
gene expression
genome wide association study
tyrosine kinase