Dynamic Involvement of Striatal NG2-glia in L-DOPA Induced Dyskinesia in Parkinsonian Rats: Effects of Doxycycline.

G C NascimentoM BortolanzaA BribianG C Leal-LuizR Raisman-VozariL López-MascaraqueElaine Del-Bel

Published in: ASN neuro (2023)

NG2-glia alters its dynamics in response to L-DOPA-induced dyskinesia. In these animals, striatal NG2-glia density was reduced with cells presenting activated phenotype while doxycycline antidyskinetic therapy promotes a return to NG2-glia cell density and protein to a not activated state.

Keyphrases

high glucose
diabetic rats
parkinson disease
functional connectivity
induced apoptosis
drug induced
single cell
stem cells
cell cycle arrest
endothelial cells
cell proliferation
mesenchymal stem cells
cell death
protein protein