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Skeletal muscle dysfunction in the db/db mouse model of type 2 diabetes.

Jeppe Seamus BayleyThomas Holm PedersenOle Baekgaard Nielsen
Published in: Muscle & nerve (2016)
The force deficit in db/db muscles was caused by atrophy and failure of neuromuscular signal transmission related to motor nerve axonal dysfunction. The slowed relaxation rate generally observed in diabetic muscles can, to a large extent, be explained by decreased SERCA pump content. Muscle Nerve 54: 460-468, 2016.
Keyphrases
  • skeletal muscle
  • type diabetes
  • mouse model
  • oxidative stress
  • insulin resistance
  • single molecule
  • peripheral nerve
  • cardiovascular disease
  • spinal cord injury
  • diabetic nephropathy