Modelling immune cytotoxicity for cholangiocarcinoma with tumour-derived organoids and effector T cells.
Guoying ZhouRuby LieshoutGilles S van TienderenValeska de RuiterMartin E van RoyenPatrick P C BoorLuc MagréJyaysi DesaiKübra KötenYik Yang KanZhouhong GeLucia Campos CarrascosaCecile GeuijenDave SprengersLuc J W van der LaanMonique M A VerstegenJaap KwekkeboomPublished in: British journal of cancer (2022)
In this proof-of-concept study, a novel CCA organoid and immune cell co-culture method was established. This can be the first step towards personalised immunotherapy for CCA by predicting which ICIs are most effective for individual patients.