Tumor-Associated Fibroblasts Promote HER2-Targeted Therapy Resistance through FGFR2 Activation.

Patricia Fernández-NogueiraMario MancinoGemma FusterAnna López-PlanaPatricia JaureguiVanesa AlmendroEstel EnreigSilvia MenéndezFederico RojoAleix Noguera-CastellsAnke BillL Alex GaitherLaia SerranoLeire Recalde-PercazNúria MoragasRaul AlonsoElisabet AmetllerAna RoviraAna LluchJoan AlbanellPere GasconPaloma Bragado

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2019)

We have identified the TAF/FGF5/FGFR2/c-Src/HER2 axis as an escape pathway responsible for HER2-targeted therapy resistance in breast cancer, which can be reversed by FGFR inhibitors.

Keyphrases

tyrosine kinase
young adults