Selective inhibition of HDAC6 promotes bladder cancer radiosensitization and mitigates the radiation-induced CXCL1 signalling.

Yu-Chieh TsaiTzu-Yin WangChia-Lang HsuWei-Chou LinJyun-Yu ChenJia-Hua LiYeong-Shiau Pu Ann-Lii Cheng Jason Chia-Hsien Cheng Sheng-Fang Su

Published in: British journal of cancer (2023)

Unlike pan-HDACi, the selective HDAC6i can enhance BC radiosensitization and effectively inhibit RT-induced oncogenic CXCL1-Snail-signalling, thus further advancing its therapeutic potential with RT.

Keyphrases

radiation induced
radiation therapy
histone deacetylase
epithelial mesenchymal transition
high glucose
diabetic rats
transcription factor
drug induced
oxidative stress
endothelial cells