Targeting ferroptosis: A novel therapeutic strategy for the treatment of mitochondrial disease-related epilepsy.

Amanda H Kahn-KirbyAkiko AmagataCeline I MaederJanet J MeiSteve SiderisYuko KosakaAndrew HinmanStephanie A MaloneJoel J BrueggerLeslie WangVirna KimWilliam D ShraderKevin G HoffJoey C LathamEuan A AshleyMatthew T WheelerEnrico BertiniRosalba CarrozzoDiego MartinelliCarlo Dionisi-ViciKimberly A ChapmanGregory M EnnsWilliam GahlLynne WolfeRussell P SanetoSimon C JohnsonJeffrey K TrimmerMatthew B KleinCharles R Holst

Published in: PloS one (2019)

These findings support the continued clinical evaluation of EPI-743 as a therapeutic agent for PCH6 and other mitochondrial diseases with associated epilepsy.

Keyphrases

oxidative stress
cell death
cancer therapy
combination therapy
drug delivery
drug induced
replacement therapy