Histone tail analysis reveals H3K36me2 and H4K16ac as epigenetic signatures of diffuse intrinsic pontine glioma.

Shejuan AnJeannie M CamarilloTina Yi-Ting HuangDaphne LiJuliette A MorrisMadeline A ZoltekJin QiMandana BehbahaniMadhuri KambhampatiNeil L KelleherJavad NazarianPaul M ThomasAmanda Muhs Saratsis

Published in: Journal of experimental & clinical cancer research : CR (2020)

Taken together, our findings provide insight into the effects of the H3K27M mutation on histone modification states and response to treatment, and suggest that H3K36me2 and H4K16ac may represent unique tumor epigenetic signatures for targeted DIPG therapy.

Keyphrases

dna methylation
genome wide
gene expression
cancer therapy
low grade
stem cells
high grade
cell therapy
mesenchymal stem cells