Effect of Increased Lactate Dehydrogenase A Activity and Aerobic Glycolysis on the Proinflammatory Profile of Autoimmune CD8+ T Cells in Rheumatoid Arthritis.
M Margarida Souto-CarneiroKarel D KlikaMónica T AbreuAndré P MeyerRainer SaffrichRoger SandhoffRichard JennemannFranziska V KrausLars TykocinskiVolker EcksteinLina CarvalhoMark KriegsmannThomas GieseHanns-Martin LorenzRui A CarvalhoPublished in: Arthritis & rheumatology (Hoboken, N.J.) (2020)
Remodeling glucose and glutamine metabolism in RA CD8+ T cells by targeting LDHA activity can reduce the deleterious inflammatory and cytolytic contributions of these cells to the development of autoimmunity.
Keyphrases
- rheumatoid arthritis
- induced apoptosis
- disease activity
- oxidative stress
- multiple sclerosis
- cell cycle arrest
- ankylosing spondylitis
- interstitial lung disease
- blood glucose
- type diabetes
- adipose tissue
- endoplasmic reticulum stress
- signaling pathway
- systemic sclerosis
- blood pressure
- cell proliferation
- systemic lupus erythematosus
- pi k akt