Cardioprotective role of IGF-1 in the hypertrophied myocardium of the spontaneously hypertensive rats: A key effect on NHE-1 activity.

A M YevesJ I BurgosA J MedinaM C Villa-AbrilleIrene Ennis

Published in: Acta physiologica (Oxford, England) (2018)

IGF-1 exerts a cardioprotective role on the hypertrophied hearts of the SHR, in which the inhibition of NHE-1 hyperactivity, as well as the positive inotropic and antioxidant effects, emerges as key players.

Keyphrases

pi k akt
binding protein
growth hormone
oxidative stress
anti inflammatory
cell proliferation