A β-hairpin peptide with pH-controlled affinity for tumor cells.
Shin-Nosuke NishimuraKei NishidaMasaru TanakaPublished in: Chemical communications (Cambridge, England) (2021)
Considering that the pH in the tumor microenvironment is dysregulated, we designed a β-hairpin peptide (SSRFEWEFESSDPRGDPSSRFEWEFESS). The configuration of the peptide switched from a flexible linear to a rigid loop structure under weakly acidic conditions. The peptide internalized by tumor cells increased significantly under weakly acidic conditions.
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