Severe Acute Respiratory Syndrome Coronavirus 2 Placental Infection and Inflammation Leading to Fetal Distress and Neonatal Multi-Organ Failure in an Asymptomatic Woman.
Sam SchoenmakersPauline SnijderRobert M VerdijkThijs KuikenSylvia S M KamphuisLaurens P KoopmanThomas B KrasemannMelek RousianMichelle BroekhuizenEric A P SteegersMarion P G KoopmansPieter L A FraaijIrwin K M ReissPublished in: Journal of the Pediatric Infectious Diseases Society (2021)
Placental infection by SARS-CoV-2 leads to fibrin depositions hampering fetal-maternal gas exchange with resulting fetal distress necessitating a premature emergency cesarean section. Postpartum, the neonate showed a fetal or pediatric inflammatory multisystem-like syndrome with coronary artery ectasia temporarily associated with SARS-CoV-2 for which admittance and care on the neonatal intensive care unit (NICU) were required, despite being negative for SARS-CoV-2. This highlights the need for awareness of adverse fetal and neonatal outcomes during the current coronavirus disease 2019 pandemic, especially considering that the majority of pregnant women appear asymptomatic.
Keyphrases
- sars cov
- respiratory syndrome coronavirus
- coronavirus disease
- coronary artery
- pregnant women
- healthcare
- oxidative stress
- public health
- palliative care
- emergency department
- metabolic syndrome
- pulmonary artery
- type diabetes
- case report
- pregnancy outcomes
- adipose tissue
- health insurance
- quality improvement
- insulin resistance
- childhood cancer
- platelet rich plasma
- preterm birth