Anti-HIV Drug Elvitegravir Suppresses Cancer Metastasis via Increased Proteasomal Degradation of m6A Methyltransferase METTL3.

Long LiaoYan HeShu-Jun LiGuo-Geng ZhangWei YuJing YangZi-Jia HuangCan-Can Zheng Qing-Yu He Yan Li Bin Li

Published in: Cancer research (2022)

This study finds that METTL3 promotes cancer metastasis by activating EGR1/Snail signaling in an m6A-dependent manner, revealing vulnerability to METTL3 blockade in esophageal squamous cell carcinoma.

Keyphrases

papillary thyroid
signaling pathway
squamous cell
epithelial mesenchymal transition
human immunodeficiency virus
hiv infected
antiretroviral therapy
climate change
hepatitis c virus
lymph node metastasis
hiv aids
young adults
drug induced